产品货号：
Z33596
中文名称：
c-Cbl/CBL抗体
英文名称：
Anti-c-Cbl/CBL Antibody (Clone#1762CT401.80.60)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-c-Cbl/CBL Antibody (Clone#1762CT401.80.60) |
| 指标别名 | C CBL;CBL;CBL2;c-Cbl;Proto oncogene c Cbl;RING finger protein 55;RNF55 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | CBL |
| 克隆号 | 1762CT401.80.60 |
| 抗体来源 | Mouse |
| 免疫原 | This CBL antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 450-644 amino acids from human CBL. |
| 计算分子量 | 100kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors.Acts as an E3 ubiquitin-protein ligase,which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes,and then transfers it to substrates promoting their degradation by the proteasome.Recognizes activated receptor tyrosine kinases,including KIT,FLT1,FGFR1,FGFR2,PDGFRA,PDGFRB,EGFR,CSF1R,EPHA8 and KDR and terminates signaling.Recognizes membrane-bound HCK,SRC and other kinases of the SRC family and mediates their ubiquitination and degradation.Participates in signal transduction in hematopoietic cells.Plays an important role in the regulation of osteoblast differentiation and apoptosis.Essential for osteoclastic bone resorption.The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function.May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. |
| Uniprot ID | P22681 |
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